Transcriptome profile of LX-2 cells [SiNSUN2]

Liver fibrosis is characterized by deposition of excessive extracellular matrix (ECM). The major source of ECM is activated hepatic stellate cells (HSCs).NSUN2 is one of the m5C methyltransferases, mainly responsible for the methylation of tRNA and mRNA and plays a significant role in RNA m5C methylation. The purpose of this transcriptome is to explore the role of NSUN2 acting as m5C methyltransferases during HSC activation. Overall design: RNA-seq profiling of LX-2 cells(con) and TGF-ß1 stimulated LX-2 cells (TGFB) and LX-2 cells transfected with NAT10 SiRNA(SiNSUN2) and then stimulated with TGF-ß1 (SiNSUN2_TGFB). *************************************************************** The table below lists GEO accessions reused/reanalyzed for this study. ***************************************************************