A new insecticidal sesquiterpene from a mangrove endophytic fungus <i>Aspergillus</i> strain sp. GXNU R1

An undescribed sesquiterpene guxinusocapsa A (<b>1</b>), featuring a unique 5/7/6 tricyclic skeleton, and three known compounds (<b>2-4</b>) was isolated from the mangrove endophytic fungus <i>Aspergillus</i> sp. GXNU R1. These isolates were established primarily through NMR data analysis. The new structure’s absolute configuration of <b>1</b> was identified by its single-crystal X-ray diffraction analysis. Compound <b>1</b> showed strong activity towards the Asian citrus psyllid (<i>Diaphorina citri</i>) with 95% lethal at 1000 mg/kg.从红树林内生真菌曲霉属（Aspergillus）菌株GXNU R1中分离得到1个未报道的倍半萜类化合物guxinusocapsa A（化合物1）与3个已知化合物（化合物2-4），其中化合物1具有独特的5/7/6三环骨架。上述分离物的结构主要通过核磁共振（NMR）数据分析得以确证。化合物1的绝对构型通过单晶X射线衍射分析确定。活性测试表明，化合物1对亚洲柑橘木虱（Diaphorina citri）具有显著杀虫活性，在1000 mg/kg剂量下致死率达95%。