File S1 - Expression of Genes Related to Anti-Inflammatory Pathways Are Modified Among Farmers’ Children

Includes Figure S1 and Tables S1–S7. Figure S1, T helper cell differentiation and B cell activation by the innate immunity. Schematic overview, how microbes activate the innate immune systems leading to T helper cell differentiation and proliferation and how immunoglobulin class switching recombination is induced via a T helper cell-dependent and independent pathway. APC, antigen-presenting cell; red, gene expression of these marker molecules was measured in this study. Table S1, list of genes their expression was assessed. Table S2, association of farm life with gene expression of TLR co-receptors, molecules of the TLR signaling cascade, and of PRR. Table S3, association of PRR, TLR co-receptors, and molecules of the TLR signaling cascade with asthma, rhinoconjunctivitis, CSR to IgE, and total or allergen-specific IgE. Table S4, association of gene expression of markers of T helper cell subtypes with asthma, rhinoconjunctivitis, CSR to IgE, and total or allergen-specific IgE. Table S5, association of gene expression of cytokines with asthma, rhinoconjunctivitis, CSR to IgE, and total or allergen-specific IgE. Table S6, association of farm life with gene expression of APRIL, BAFF, CD40L, and AICDA. Table S7, association of gene expression of APRIL, BAFF, CD40L, and AICDA with asthma, rhinoconjunctivitis, CSR to IgE, and total or allergen-specific IgE.
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