Transmission at SNPs showing biased gene conversion in NCOs at hotspots F and K.

Men are numbered as in refs 5, 9 & 37. The combined number of molecules screened in the two orientations is shown for each man. Poisson-corrected numbers of recombinants are rounded up to the next integer; this Poisson-correction was modest, with observed CO numbers increased by a factor of 1.17 and 1.03 for hotspots F and K respectively, and NCO numbers being increased by a factor of 1.14 and 1.06 respectively. There is no evidence for heterogeneity between individuals in the strength of TD in NCOs in favour of F6.1G or K7.4C (hotspot F: P = 0.83, 2×10 contingency table, 9 d.f.; hotspot K: P = 0.24, 2×8 contingency table, 7 d.f.). Marginally significant variation between individuals was noted for COs at hotspot F (P = 0.047, 2×10 contingency table, 9 d.f.) but no significant variation for this class of recombinant amongst the men screened at hotspot K (P = 0.11, 2×8 contingency table, 7 d.f.).