Activation of conventional Protein Kinase C

Protein Kinase C (PKC) is positively regulated by events that increase the plasma membrane concentration of diacylglycerol (DAG). Activation of PKC requires the coordinated binding of two membrane-targeting domains. The C1 domain binds diacylglycerol, the C2 domain binds phosphatidylserine. Each can bind the membrane independently, but with insufficient affinity for membrane recruitment and activation.

蛋白激酶C（PKC）受细胞质膜中二酰甘油（DAG）浓度增加事件的正向调控。PKC的激活需依赖于两个膜靶向结构域的协同结合。C1结构域结合二酰甘油，C2结构域结合磷脂酰丝氨酸。两者均能独立结合膜结构，但亲和力不足，无法有效招募至膜上并激活。