Exploring differentially expressed lncRNAs between the osteosarcoma and adjacent normal tissues using RNA-Seq method

Osteosarcoma is one of the most commonly primary malignant tumors of bone, and the five-year survival rate for osteosarcoma patients is not satisfactory. Dysregulations of lncRNAs are frequently found in multiple cancers, including osteosarcoma, and these data reveal the critical involvement of lncRNAs in the tumorigenesis. Osteosarcoma tissues and adjacent normal tissues for controls were obtained and analyzed by high-throughput sequencing. Our data showed that hundreds of lncRNAs were identified, with LINC00673 ranking first among all the up-regulated lncRNAs. This study suggests that different expressions of lncRNAs may involve in the potential function in osteosarcoma and provide a novel insight for diagnosis of this disease. Overall design: RNA-seq profiling of human osteosarcoma tissues and paired adjacent normal tissues was performed to identify differentially expressed lncRNAs.