Exosomal-RBPs that formed complexes with esRNA, cell-miRNA or cell-mRNA.

In total, 30 different RBPs were identified in exosomes, including 20 in complex with esRNA. Out of these 20 RBPs, 12 are exclusive to esRNA, 2 were common between the esRNA and cell-mRNA samples, 2 were common between the esRNA and cell-miRNA samples and 4 were common in all three samples i.e. esRNA, cell-mRNA and cell-miRNA. 9 exosomal-RBPs were in complex with cell-miRNA, 14 in complex with cell-mRNA and 1 was common between cell-miRNA and cell-mRNA samples. 2 exosomal-RBPs were in complex with cell-miRNA only, and 7 were in complex with cell-mRNA only. The protein domains may have distinct binding preferences to target RNA sequence motifs available at RBP database (http://rbpdb.ccbr.utoronto.ca/).