T. cruzi PCM inhibits expression of a subset of TGFß-inducible genes.

Human foreskin fibroblasts were treated with medium or 5 ng/ml TGF- ß1 for 3 hours in the presence and absence of T. cruzi PCM.TGF-ß1 treatment resulted in a ≥2-fold up-regulation of 298 unique genes (represented in 309 probe-sets) as compared to cells treated with medium. Genes highlighted above represent the 59 annotated, non-redundant TGF-ß-inducible genes for which expression is reduced by 1.7-fold or greater in the presence of T. cruzi PCM in 3 independent experiments. * Values represent the ratio of the normalized log2 intensities for treatment (TGF-ß or TGF-ß/PCM)/mock treated controls.