Distributions of the model parameters used in the probabilistic sensitivity analysis and point estimates with confidence intervals between brackets.

aDerived from observed number of events [14], [18].bOne year-probabilities were derived from observed number of events [14], [18]. One-year probabilities were transformed into 4-week probabilities assuming a constant hazard rate.cYearly costs derived from Smit et al. using method of moments [15]. Yearly costs were divided by 13 and multiplied by price indices to obtain costs per cycle. Societal costs include health care costs but exclude the costs of work cut-back as reported in Smit et al. [15] as these were not included in the studies used to estimate societal costs associated with major depression [20]–[22].dDistribution was derived from a sample of Dutch physicians' estimation of the utility of sub-threshold depression (0.903, 95%CI 0.849–0.956) (Smit et al., unpublished study).eYearly costs derived using random effect meta analyses from 3 studies [20]–[22]. Yearly costs were divided by 13 and multiplied by price indices to obtain costs per cycle. Societal costs include health care costs.