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Pharmacological Repositioning of the transcription factor PU.1 [CUTnTag]

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE267385
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This study aims to investigate the effects of PU.1 binding-site inhibitors/redistributors (DB2115, DB2373, DB2750, DB2826) upon the genomic occupancy of PU.1 and to understand DB2115-binding site preference amongst the PU.1 cistrome. MOLM-13, JURKAT & primary AML cells were treated with 5uM of DB compound for 12hr before cells were harvested for PU.1, RUNX1, GATA3, ELF1, FLI1 or GABPA CUT&Tag.
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2024-12-13
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