Fig.4D. SARS-MERS comparison : Virus-human protein-protein interaction map

The network depicts interactions derived from cluster 2 (all 3 viruses), cluster 4 (SARS-CoV-1 and SARS-CoV-2), and cluster 5 (MERS-CoV only). Edge color denotes DIS: red, interactions specific to SARS-CoV-1 and SARS-CoV-2 but absent in MERS-CoV; blue, interactions specific to MERS-CoV but absent from both SARS-CoV-1 and SARS-CoV-2; black, interactions shared between all three viruses. Human-human interactions (thin dark grey line), proteins sharing the same protein complexes or biological processes (light yellow or light blue highlighting, respectively) are shown. Host-host physical interactions, protein complex definitions, and biological process groupings are derived from CORUM (39), Gene Ontology (biological process), and manually curated from literature sources. Thin dashed grey lines are used to indicate the placement of node labels when adjacent node labels would have otherwise been obscured. DIS = differential interactions score; SARS2 = SARS-CoV-2; SARS1 = SARS-CoV-1; MERS = MERS-CoV; SARS = both SARS-CoV-1 and SARS-CoV-2.