BACE-1 in complex with (7aR)-7a-(5-cyanothiophen-2-yl)-6-(4-ethoxy-5-fluoro-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium

BACE-1 in complex with (7aR)-7a-(5-cyanothiophen-2-yl)-6-(4-ethoxy-5-fluoro-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium Descriptor: 5-[(2E,4aR,7aR)-6-(4-ethoxy-5-fluoro-6-methylpyrimidin-2-yl)-2-imino-3-methyl-4-oxooctahydro-7aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophene-2-carbonitrile, Beta-secretase 1 Authors: Orth, P. Deposit date: 2016-01-05 Release date: 2016-03-16 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.602 Å) Cite: Structure-Based Design of an Iminoheterocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central A beta in Nonhuman Primates. J.Med.Chem., 59, 2016

BACE-1与(7aR)-7a-(5-氰基噻吩-2-基)-6-(4-乙氧基-5-氟-6-甲基嘧啶-2-基)-3-甲基-4-氧代八氢-2H-吡咯并[3,4-d]嘧啶-2-亚胺鎓形成的复合物。描述符：5-[(2E,4aR,7aR)-6-(4-乙氧基-5-氟-6-甲基嘧啶-2-基)-2-亚氨基-3-甲基-4-氧代八氢-7aH-吡咯并[3,4-d]嘧啶-7a-基]噻吩-2-甲腈，β分泌酶1（Beta-secretase 1）；作者：Orth, P.；提交日期：2016-01-05；发布日期：2016-03-16；最后修改日期：2024-11-13；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率为1.602埃（Å）；引用文献：《基于结构设计可降低非人灵长类动物中枢Aβ水平的亚氨基杂环类β位淀粉样前体蛋白裂解酶1（BACE）抑制剂》，《药物化学杂志》（*Journal of Medicinal Chemistry*），2016年，第59卷。