Blood samples from COPD subjects and Healthy Volunteers taken before and after LPS challenge

There is a need for non-invasive imaging protocols to support early phase clinical studies for drugs targeting neutrophilic inflammation. The aim of the study was to quantify whole lung neutrophil accumulation in (i) healthy volunteers (HV) following inhaled lipopolysaccharide (LPS) or saline and (ii) stable COPD patients, using radiolabelled autologous neutrophils and single-photon-emission/computed-tomography (SPECT/CT). Whole Blood samples for biomarker analysis were taken at baseline in 20 COPD subjects and in 18 HVs pre and post challenge with LPS