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Selective Loss of RB in Resistant EGFR Mutant Lung Adenocarcinomas that Transform to SCLC

ChEBI2015-01-30 更新2026-07-21 收录

肿瘤耐药机制

肿瘤亚型转化

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-64766 数据链接链接失效反馈

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Selective Loss of RB in Resistant EGFR Mutant Lung Adenocarcinomas that Transform to SCLC

应用场景：

创建时间：

2015-01-30

肿瘤耐药机制

靶向药物组合

Fifty percent of cutaneous melanomas are driven by activated BRAFV600E, but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there i

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MiRNA expression data from TMZ-resistant GBM cell line

肿瘤耐药机制

miRNA表达谱

Glioblastoma multiforme(GBM) is the most common and lethal malignant primary brain tumor. Temozolomide (TMZ) is a promising chemo-therapeutic agent to treat GBM. However, resistance to TMZ develops qu

NIAID Data Ecosystem80

Mesenchymal tumor cells drive adaptive resistance of Trp53-/- breast tumor cells to inactivated mutant Kras

肿瘤耐药机制

MAPK信号通路

As precision medicine increases the response rate of treatment, tumors frequently bypass inhibition and reoccur. In order for treatment to be effective long term, the mechanisms enabling treatment ada

NIAID Data Ecosystem60

Gene expression profiling in carmustine-resistant melanoma A2058 cells

肿瘤耐药机制

基因表达谱分析

Analysis of gene expression and compare the significant changed genes with associated phenotypes. Total RNA extracted from parental or carmustine-resistant A2058 cells.

NIAID Data Ecosystem80

AZ1366: An inhibitor of tankyrase and the canonical Wnt pathway that limits the persistence of non-small cell lung cancer cells following EGFR inhibition. Homo sapiens

肿瘤耐药机制

组合治疗

EGFR-mut NSCLC lines show differential suceptibility to inhibition of tankyrase in the presence of EGFR inhibitors Overall design: NSCLC cells were treated in quadruplicate with gefitinib, AZ1366 (tan

NIAID Data Ecosystem80

Selective Loss of RB in Resistant EGFR Mutant Lung Adenocarcinomas that Transform to SCLC

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