Additional file 1 of Relationships between circulating metabolites and facial skin aging: a Mendelian randomization study

Additional file1: Figure S1. Heatmap showing the causal estimates of triglycerides related traits on facial skin aging in the primary analyses with IVW, MR-Egger, and weighted median methods. Figure S2. Heatmap showing the causal estimates of amino acids on facial skin aging in the primary analyses with IVW, MR-Egger, and weighted median methods. Figure S3. Heatmap showing the causal estimates of cholesterol ester on facial skin aging in the primary analyses with IVW, MR-Egger, and weighted median methods. Figure S4. Heatmap showing the causal estimates of free cholesterol on facial skin aging in the primary analyses with IVW, MR-Egger, and weighted median methods. Figure S5. Heatmap showing the causal estimates of lipoprotein cholesterol on facial skin aging in the primary analyses with IVW, MR-Egger, and weighted median methods. Figure S6: Heatmap showing the causal estimates of small metabolites on facial skin aging in the primary analyses with IVW, MR-Egger, and weighted median methods. Figure S7. Heatmap showing the causal estimates of phospholipids on facial skin aging in the primary analyses with IVW, MR-Egger, and weighted median methods. Figure S8. Heatmap showing the causal estimates of total lipids on facial skin aging in the primary analyses with IVW, MR-Egger, and weighted median methods. Figure S9. Heatmap showing the causal estimates of 123 metabolic traits on facial skin aging in the secondary analyses with IVW, MR-Egger, and weighted median methods. Figure S10. Dot plot of Cook’s distance for the causal effects of degree of unsaturation on facial skin aging with MR-BMA method. Figure S11. Dot plot of Cook’s distance for the causal effects of MUFA on facial skin aging with MR-BMA method. Figure S12. Dot plot of Cook’s distance for the causal effects of PUFA to MUFA ratio on facial skin aging with MR-BMA method. Figure S13. Dot plot of Q-statistics for the causal effects of degree of unsaturation on facial skin aging with MR-BMA method.