Neighbourhood child population density as a proxy measure for exposure to respiratory infections in the first year of life: A validation study

BackgroundAssessing exposure to infections in early childhood is of interest in many epidemiological investigations. Because exposure to infections is difficult to measure directly, epidemiological studies have used surrogate measures available from routine data such as birth order and population density. However, the association between population density and exposure to infections is unclear. We assessed whether neighbourhood child population density is associated with respiratory infections in infants.MethodsWith the Basel-Bern lung infant development study (BILD), a prospective Swiss cohort study of healthy neonates, respiratory symptoms and infections were assessed by weekly telephone interviews with the mother throughout the first year of life. Using population census data, we calculated neighbourhood child density as the number of children ResultsThe analyses included 487 infants. We found no evidence of an association between quintiles of neighbourhood child density and number of respiratory symptoms (p = 0.59, incidence rate ratios comparing highest to lowest quintile: 1.15, 95%-confidence interval: 0.90–1.47). There was no evidence of interaction with older siblings (p = 0.44). Results were similar in crude and in fully adjusted models.ConclusionsOur study suggests that in Switzerland neighbourhood child density is a poor proxy for exposure to infections in infancy.