Ba/F3 cells expressing ETV6-PDGFRb and FIP1L1-PDGFRa treated or not with Glivec

ChEBI2014-03-21 更新2026-07-21 收录

白血病靶向治疗

激酶抑制剂药效评估

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-44810 数据链接链接失效反馈

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资源简介：

Ba/F3 cells expressing ETV6-PDGFRb and FIP1L1-PDGFRa treated or not with Glivec

创建时间：

2014-03-21

Combined ANA and IDA treatment is an innovative and promising therapeutic strategy for AML patients with high PDE3A expression

白血病靶向治疗

药物协同作用

Acute myeloid leukemia (AML) is an invasive hematopoietic malignancy requiring novel treatment strategies. The PDE3A inhibitor anagrelide (ANA) profoundly suppresses the proliferation of high PDE3A-ex

NIAID Data Ecosystem120

A Multi- Kinase Inhibitor Modulates Pulmonary Hypertension in a Rodent Model

肺动脉高压动物模型

激酶抑制剂药效评估

Pulmonary hypertension (PH) and cancer pathophysiology share common signal transduction pathways leading to abnormal endothelial and smooth muscle cell interactions and angioproliferative vasculopathy

NIAID Data Ecosystem60

A potent and selective small-molecule degrader of ENL suppresses leukemia progression in vivo (ChIP-Seq)

白血病靶向治疗

蛋白降解靶向嵌合体

ENL, a stoichiometric component of the Super Elongation Complex (SEC) as well as the histone H3K79 methyltransferase DOT1L complex, is involved in the regulation of transcription elongation. Loss-of-f

NIAID Data Ecosystem30

Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia

白血病靶向治疗

ATP（三磷酸腺苷）

The chromatin-associated AAA+ ATPases Tip48 and Tip49 are the core components of various complexes implicated in diverse nuclear events such as DNA repair and gene regulation. Although they are freque

NIAID Data Ecosystem60

A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells

干细胞自我更新机制

白血病靶向治疗

The transcription factors STAT5A and STAT5B are critical in hematopoiesis and leukemia. They are widely believed to have redundant functions but we describe a unique role for STAT5B in driving the sel

NIAID Data Ecosystem40

Ba/F3 cells expressing ETV6-PDGFRb and FIP1L1-PDGFRa treated or not with Glivec

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