Supplementary Tables for PheWAS of PRRC2C: Phenome-Wide Associations Across Binary and Quantitative Traits

This dataset contains the complete PheWAS (phenome-wide association study) results for the PRRC2C gene, which was identified as a putatively causal gene for obesity through multi‑omics integration and Mendelian randomization. Table S4 (supplementary_set4.csv): Association results for PRRC2C with 17,361 binary phenotypes. For each phenotype, the table provides the P-value, Odds Ratio (OR), and the number of cases and controls with the qualifying variant across different ancestries and collapsing models. Table S5 (supplementary_set5.csv): Association results for PRRC2C with 1,419 quantitative/continuous phenotypes. For each phenotype, the table provides the effect size, P-value, and sample size. These PheWAS analyses were conducted to assess the pleiotropic effects of genetically predicted PRRC2C expression. No significant associations reached the genome‑wide significance threshold (*p* < 5×10⁻⁸), suggesting limited evidence of broad pleiotropy for PRRC2C across the tested phenotypes. The data are derived from the AstraZeneca PheWAS Portal and are provided as supplementary materials for the associated manuscript.