Severe enteritis in dogs associated with single and mixed infections

ABSTRACT: Infectious enteritis is highly prevalent among dogs worldwide and, in some cases, it can be fatal. This study describes the clinical and laboratorial findings of single and mixed infections associated with severe enteritis in 76 dogs from Southern Brazil. Intestinal segments and/or fecal samples were subjected to histopathology and molecular detection of DNA viruses, bacteria and protozoa. Severe intestinal lesions were observed in most cases. Single infections were detected in 52.6% of cases, double (36.8%) and triple (10.5%) infections were also identified. Carnivore protoparvovirus 2 (CPV-2) was the most frequent agent in single infections (36.8%). Coinfection by CPV-2 and Giardia spp. was the most common in dual infections (19.7%), followed by CPV-2 and Cryptosporidium spp. (10.5%). The most frequent triple infection was CPV-2, Giardia sp. and Cryptosporidium spp. (6.6%). Our results shown that single and mixed infections are associated with severe enteritis in dogs in southern Brazil, mainly involving CPV-2 and Giardia sp.摘要：犬传染性肠炎在全球范围内具有极高流行率，部分病例可导致致命性后果。本研究针对巴西南部地区76例重症肠炎犬只，阐述了其单一感染与混合感染的临床及实验室检测结果。研究人员对肠道组织片段及/或粪便样本开展了组织病理学检查，并对DNA病毒、细菌与原虫进行了分子检测。多数病例可见严重肠道病变。单一感染检出率为52.6%，此外还检出双重感染（36.8%）与三重感染（10.5%）。食肉动物原细小病毒2型（Carnivore protoparvovirus 2，CPV-2）是单一感染中最常见的病原体，占比达36.8%。CPV-2与贾第鞭毛虫属（Giardia spp.）合并感染为双重感染中最常见的类型（19.7%），其次为CPV-2与隐孢子虫属（Cryptosporidium spp.）合并感染（10.5%）。最常见的三重感染为CPV-2、贾第鞭毛虫属与隐孢子虫属合并感染，占比6.6%。本研究结果显示，巴西南部地区犬只的重症肠炎与单一感染及混合感染密切相关，其中主要涉及CPV-2与贾第鞭毛虫属。