Differential expression of microRNAs between health and cachectic naked mole rat

Enrichment of the habitat of captive rodents Heterocephalus glaber (naked mole rats) to implement their innate behavioral pattern of digging dense soil in search of food, paradoxically led to the appearance of unusual animals in the colony. They showed signs of cachexia, distinguished from other animals by a lower temperature (from 31 to 26 degree) and body mass index with decreasing proportion of subcutaneous fat. This animal demonstrated aggressive feeding behavior, but didnt gain weight even after finishing of experiment with intensive physical activity.To clarify the pathogenetic mechanism of the observed phenomenon, microRNA was extracted from the animal tissues and sequenced. Then bioinformatics analysis differential expression of microRNAs between group of health animals and animals with idiopatic cachexia was performed.