Performance assessment of molecular connectivity maps for several representative cancers.

The table shows a comparison of performance measures—sensitivity, specificity, PPV (positive predictive value), F-score, and ACC (accuracy)—for six major cancer drug identification tasks. The evaluation procedure and the development of “gold standard” for each cancer study follows the same method developed for AD. The complete set of all the drugs identified for the 6 cancers is shown in Dataset S4, which contains information on False Discover Rate (FDR), Document Frequency (DF) in the retrieved PubMed abstract corpus, Pharmacological Action, and validation flags (Found In GS and Found In DrugBank) for each drug.