The myth of subarachnoid hemorrhage-weather: A long-term big-data and deep-learning analysis. Supplementary Data.

Objective: Frequency of aneurysmal subarachnoid hemorrhage (aSAH) presents complex fluctuations that have been attributed to weather and climate changes in the past. In this long-term
big-data and deep-learning analysis, we strive to finally refute this myth.

Methods: Bleeding dates and basic demographic data for all consecutive patients (n = 1271) admitted to our vascular center for treatment of aSAH between January 2003 and May 2020 (6334 days) were collected from our continuously maintained database. Meteorological data of the local weather station, including 13 different weather and climate parameters were retrieved from Germany's National Meteorological Service for the same period. Six different deep learning models were programmed using the Keras framework and were trained for aSAH event prediction with meteorological data from January 2003 to June 2017 with 10% of this dataset applied for data validation and model improvement. The dataset from July 2017 to May 2020 was tested for aSAH event prediction accuracy for all six models using the area under the receiver operating characteristic curve (AUROC) as the metric.