Mechanistic investigation of probiotic formula combined with berry extracts on intestinal health in the elderly: a randomised, double-blind, placebo-controlled clinical trial

we carried out a double-blind, placebo-controlled clinical trial to evaluate the protective effects and underlying mechanisms of a compound probiotic product on the gut health of elderly individuals with functional constipation. This study primarily focuses on the changes in intestinal barrier indicators potentially associated with intestinal aging. Simultaneously, constipation-specific and ancillary questionnaires were adopted to evaluate bowel movements and the symptoms induced by constipation. To deeper understand the relationship between gut microbiota and intestinal aging, we carried out the 16S rRNA gene sequencing and ungtageted metabolome at different phases.
This research was funded by Amway (Shanghai) Innovation & Science Co., Ltd. , China