Intra Class Correlation coefficients for all participants (n = 46).

ICC: Intra-class correlation coefficient (2, 1). Inter refers to inter-observer reproducibility, intra to intra-observer reproducibility. The manual protocol included manual image selection and manual image analysis. The semi-automated protocol included manual image selection and automated analysis. The fully-automated protocol included automated image selection and automated analysis. CNFL, corneal nerve fibre length. CNFD, corneal nerve fibre density. CNBD, corneal nerve branch density.* Manual protocol ICC have been presented in a previous publication and are shown here for comparison.† For the 11-member sub-population with CNFL below 12.3mm/mm2, the inter-observer ICC for CNFLManual, CNFLSemi-Automated, and CNFLFully-Automated were 0.54(-0.09,0.85), 0.51(-0.04,0.83), and 0.73(0.25,0.92), respectively. P-values for comparison of the ICC of CNFLSemi-Automated to CNFLManual, CNFLFully-Automated to CNFLManual, and CNFLFully-Automated to CNFLSemi-Automated were 0.56, 0.17, and 0.15, respectively. The corresponding intra-observer ICC for CNFLManual, CNFLSemi-Automated, and CNFLFully-Automated were 0.74(0.26,0.92), 0.68(0.20,0.90), and 0.86(0.55,0.96), respectively. The p-values for the corresponding comparisons were 0.64, 0.16, and 0.19.Intra Class Correlation coefficients for all participants (n = 46).