Aspergillus fumigatus Genome sequencing. Aspergillus fumigatus

Lines evolved for resistance to SI fungicides were whole genome sequenced to uncover the genetic underpinning of phenotypic differences found. Lines that showed increased resistance to environmentally used fungicides, also show increased resistance against medically used fungicides. The increases of this resistance in evolutionary times could be explained by mutations found in genes previously described to confer fungicide resistance as well as in genes previuously not described to confer resistance.