Strain-Promoted Oxidative Annulation of Arynes and Cyclooctynes with Benzamides: Palladium-Catalyzed C–H/N–H Activation for the Synthesis of N‑Heterocycles

Strained alkynes include arynes and cyclooctynes reacted with N-methoxyamides through palladium-catalyzed C–H/N–H activation for the first time. A variety of important N-heterocycles such as phenanthridinones and isoquinolones were constructed in one step with high efficiency.