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Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

ChEBI2006-09-12 更新2026-07-21 收录

RNA干扰脱靶效应

siRNA设计优化

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-5814 数据链接链接失效反馈

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资源简介：

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

应用场景：

创建时间：

2006-09-12

siRNA设计优化

RNA干扰治疗

The design of small interfering RNA (siRNA) is a multi factorial problem that has gained the attention of many researchers in the area of therapeutic and functional genomics. MysiRNA score was previou

Figshare2016-10-28 更新90

Assigned threshhold scores using the Huesken dataset to analyse each scoring tool to two thresholds to filter siRNA with expected inhibition efficiency 90%.

siRNA设计优化

RNA干扰机制

Assigned threshhold scores using the Huesken dataset to analyse each scoring tool to two thresholds to filter siRNA with expected inhibition efficiency 90%.

Figshare2016-10-28 更新50

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. Homo sapiens

RNA干扰脱靶效应

基因沉默机制

Transfected siRNAs and miRNAs regulate numerous transcripts that have only limited complementarity to the active strand of the RNA duplex. This process reflects natural target regulation by miRNAs, bu

NIAID Data Ecosystem30

Probing the off-target effect of EGFP siRNA and pro-siRNA in the HeLa-d1EGFP cell line

RNA干扰脱靶效应

siRNA设计优化

We have develped a novel method of making siRNAs (named pro-siRNA for prokaryotic siRNA). To evaluate off-targeting of pro-siRNA, we compared the mRNA expression profiles of HeLa-d1EGFP cells transfec

NIAID Data Ecosystem50

Reduced seed region-based off-target activity with lentivirus-mediated RNAi

RNA干扰脱靶效应

慢病毒载体

In addition to silencing intended target genes, transfected siRNAs regulate numerous unintended transcripts through a mechanism in which the equivalent of a microRNA-like seed region in the siRNA reco

NIAID Data Ecosystem40

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

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