MOESM1 of The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients

Additional file 1: Table S1. Type of the bariatric surgery in 40 severely obese patients. Table S2. Baseline and follow-up characteristics of severely obese cohort before and 12 months after bariatric surgery. Table S3. 4857 significant CpG sites associated with pre- and post bariatric surgery difference form EWAS analysis. Table S4. Correlations of change in DNA methylation with change in clinical measures in pre- and post-surgery cohort. Table S5. Reactome enriched terms based on EWAS results. Table S6. Gene ontology terms enriched based on correlated with clinical traits CpG sites from DAVID software. Table S7. Top 10 gene ontology terms enriched based on correlated with clinical traits CpG sites from Metacore software. Table S8. Top 10 gene-dieseses assotiations enriched based on correlated with clinical traits CpG sites from Metacore software. Table S9. Top 30 trancription factors calculated based on a correlated CpG sites with clinical traits by Metacore software. Table S10. TCF7L1 and LMO2 transcription factore and their associated genes from Metacore software. Table S11. DNA methylation levels significantly associated with gene expression levels from blood derived from publically available data (https://www.genenetwork.nl/biosqtlbrowser/). Table S12. 4857 significant CpG sites associated with pre-and post bariatric surgery difference from EWAS analysis separately for 3 cohorts and a combined effect. Table S13. Characteristics of 2 Lifelines subcohorts, healthy lean and healthy obese.