A Nucleosome Destabilizing Factor that Facilitates Transcription in Chromatin

ChEBI2019-01-25 更新2026-07-12 收录

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核小体去稳定因子

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-6466 数据链接链接失效反馈

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A Nucleosome Destabilizing Factor that Facilitates Transcription in Chromatin

创建时间：

2019-01-25

Mutant Versions of the S. cerevisiae Transcription Elongation Factor Spt16 Define Regions of Spt16 That Functionally Interact with Histone H3

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FACT复合物

In eukaryotic cells, the highly conserved FACT (FAcilitates Chromatin Transcription) complex plays important roles in several chromatin-based processes including transcription initiation and elongatio

NIAID Data Ecosystem110

H3mm18 interferes with transcription on H3.3 incorporated chromatin.. H3mm18 interferes with transcription on H3.3 incorporated chromatin.

组蛋白变体功能

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We focused on H3mm18 (one of the histone H3.3 subvariants that is expressed in skeletal muscle stem cells) to understand the function of a group that is not incorporated into chromatin. Overall design

NIAID Data Ecosystem70

NDF-FACT phase separation condensates are required for RNA Polymerase II transcription elongation through chromatin [ChIP-Seq]

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相分离

Eukaryotic gene expression requires factors that assist RNA polymerase in transcribing through nucleosomes. Human FACT complex (Facilitates chromatin transcription) was originally discovered as an imp

NIAID Data Ecosystem10

DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ChIPseq]

DNAG-四链体调控

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G4s are nucleic acids secondary structures that form in the presence of four or more runs of gunanine. In vitro results suggested that G4s are involved in the regulation of both transcription and repl

NIAID Data Ecosystem110

Expression data in histone-depleted cells [gene-level]

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剪接分析

How chromatin controls transcription elongation and splicing is an open question. Here we determine the transcriptomic changes of cells partially depleted of core histones. For that we construct a cel

NIAID Data Ecosystem40

A Nucleosome Destabilizing Factor that Facilitates Transcription in Chromatin

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