RNA sequencing of wildtype and homozygous titin A178D mouse left ventricle samples
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Truncating variants in titin can cause dilated cardiomyopathy, however, the role of missense titin variants is less clear. In humans the heterozygous titin A178D variant is associated with dilated cardiomyopathy with left ventricular non-compaction. Using CRISPR-Cas9 mediated homology-directed repair the A178D titin variant was introduced into a mouse model. Homozygous A178D mice showed features of dilated cardiomyopathy. Total RNA was extracted from the left ventricles of WT and homozygous A178D littermate control mice and RNA-sequencing performed. Different patterns of gene expression were identified in wildtype and homozygous A178D left ventricles.
提供机构：
Univeristy of Oxford
创建时间：
2022-02-20
