PYCR2 complexed with NAD+ and (2S)-2-hydroxy-3,3-dimethylbutanoic acid
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PYCR2 complexed with NAD+ and (2S)-2-hydroxy-3,3-dimethylbutanoic acid Descriptor: (2S)-2-hydroxy-3,3-dimethylbutanoic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 2, ... Authors: Tanner, J.J, Meeks, K.R. Deposit date: 2025-08-22 Release date: 2026-05-20 Last modified: 2026-05-27 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Targeting a Unique Cysteine Residue to Achieve Isoform-Selective Inhibition of the Proline Biosynthetic Enzyme Pyrroline-5-Carboxylate Reductase 2. Acs Chem.Biol., 21, 2026
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2025-08-22
