Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Cyclofenil-ASC derivative, ethyl (E)-3-(4-(bicyclo[3.3.1]nonan-9-ylidene(4-hydroxyphenyl)methyl)phenyl)acrylate

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Cyclofenil-ASC derivative, ethyl (E)-3-(4-(bicyclo[3.3.1]nonan-9-ylidene(4-hydroxyphenyl)methyl)phenyl)acrylate Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, ethyl 3-(4-{[(1s,5s)-bicyclo[3.3.1]nonan-9-ylidene](4-hydroxyphenyl)methyl}phenyl)prop-2-enoate Authors: Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. Deposit date: 2016-10-13 Release date: 2017-01-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017

与环芬尼-ASC衍生物（(E)-3-(4-(双环[3.3.1]壬烷-9-亚基(4-羟苯基)甲基)苯基)丙烯酸乙酯）结合的ERα（雌激素受体α，Estrogen Receptor α）配体结合域（Y537S突变体）的晶体结构
数据集描述：雌激素受体（Estrogen Receptor, ER）、核受体辅激活因子2（Nuclear receptor coactivator 2, NCOA2）、(E)-3-(4-{(1S,5S)-双环[3.3.1]壬烷-9-亚基(4-羟苯基)甲基}苯基)丙-2-烯酸乙酯
作者：Nwachukwu, J.C.、Erumbi, R.、Srinivasan, S.、Bruno, N.E.、Nowak, J.、Izard, T.、Kojetin, D.J.、Elemento, O.、Katzenellenbogen, J.A.、Nettles, K.W.
提交日期：2016-10-13
发布日期：2017-01-18
最后修改日期：2024-03-06
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.24埃（Å）
引用文献：《配体对ERα影响的系统结构生物学分析可预测细胞对环境雌激素与抗激素治疗的响应》，发表于Cell Chemical Biology（Cell Chem Biol），2017年，第24卷