Aldafermin-producing E.coli Nissle 1917 effects on liver and adipose tissue gene expression profile of NAFLD mouse model

To investigate aldafermin-producting E.Coli Nissle 1917 effects in combination with dietary changes in NAFLD mouse model. Overall design: NAFLD was induced in C57BL/6J male mice by American lifestyle-induced obesity syndrome diet and then switched to a standard chow diet for seven weeks. In addition to the dietary change, the intervention group received genetically engineered E.coli Nissle expressing aldafermin and the liver and epididymal adipose tissue gene expression profile was evaluated after the intervention. Two control groups were included during seven weeks of interventions: control1: NAFLD mouse model fed by chow diet; control 2: NAFLD mouse model receiving E.Coli Nissle 1917 without expression of peptides.