MOESM3 of Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice

Additional file 3: Table S1. Permutational multivariate analysis of variance (PERMANOVA) of EFAD mice stratified by APOE, sex, APOE + sex. (A) PERMANOVA was used to assess the effect of the interaction between universal biological variables on the microbiome composition at various taxonomic levels. P-values were obtained using 9999 permutations under a reduced model. Pseudo-F ratio is defined by the difference between cohorts over the difference within each cohort and the degrees of freedom. Each term is contributing a fixed component to the overall model. Estimated sizes of components of variation are multivariate analogs to the classical ANOVA unbiased estimators. Significance (bold) is defined by a p < 0.05. (B) As the interaction between APOE + sex is significant, pair-wise PERMANOVAs at the OTU level evaluated the effects of APOE on β-diversity within ♂EFAD and ♀EFAD mice, and the effects of sex in E3FAD and E4FAD. Significance (bold) is defined by a p < 0.05.