Synthesis of a Potential Intermediate for TMC-95A via an Organocatalyzed Aldol Reaction
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/Synthesis_of_a_Potential_Intermediate_for_TMC_95A_via_an_Organocatalyzed_Aldol_Reaction/2370205
下载链接
链接失效反馈官方服务：
资源简介：
N-Prolinylanthranilamide-based
pseudopeptide
organocatalyst 14 was shown to promote enantioselective
direct aldol reaction of 7-iodoisatin and 2,2-dimethyl-1,3-dioxan-5-one
with 90% conversion (75% isolated yield), 90% enantioselectivity,
and 23:1 diastereoselectivity. To demonstrate the synthetic utility
of this chemistry, the racemic aldol reaction product was converted
in five steps to a potential intermediate for construction of the
natural product TMC-95A.
创建时间：
2016-02-18
