Genome-wide mRNA profiling of styrene oxide effects in human induced pluripotent stem cells-derived neurons

In this study, we used human cortical neurons derived from induced pluripotent stem cell lines (N1) to identify universal transcriptomic signatures of styrene oxide neurotoxicity, to highlight novel pathways responsible for its biological activity, and to unravel potential associations with autism spectrum disorders. Total RNA was extrated from cells after 24h exposure to 100µM styrene oxide or vehicle and subjected to RNA sequencing. Overall design: Examination of styrene oxide effects in human induced pluripotrnt stem cells-derived cortical neurons