Mapping the plasma proteomic architecture of systemic lupus erythematosus

Proteomics data were generated by SomaLogic's SomaScan v4.1 assay for plasma samples obtained from SLE patients and healthy volunteers in two batches: batch A and batch B. This data deposition includes: Metadata for the protein features ("SOMAmers") measured by the SomaScan v4.1 assay. Protein abundance levels for each SOMAmer in all samples included in the study. Metadata for each sample. The sample metadata includes the following columns: Column name Data type Description SampleId Character Unique identifiers for samples DonorId Character Unique identifiers for individuals Included_in_study Character Whether the sample was included in any analysis of our study after exclusion due to QC or repeated sampling's criteria Group Character Sample group; whether the individual was a patient of SLE or healthy volunteer (HV) Batch Character Whether the sample was measured by SomaScan in batch A or batch B Age_group Character Age group in 5-year intervals of the individual at the time of sampling Sex Character The individual's sex (F or M) Multiple_timepoints_available Character Whether there were multiple samples obtained from the same donor at different timepoints Duration_years Numeric Disease duration (in years) at the time of sampling since diagnosis C3_level Numeric Clinically measured complement C3 level at the time of sampling C4_level Numeric Clinically measured complement C4 level at the time of sampling SLEDAI_2K Integer The SLE Disease Activity Index-2K score at the time of sampling Disease_activity Character Sample's disease activity defined by the DORIS criteria. LDA = Low disease activity; MDA = Moderate disease activity; HDA = High disease activity LN_group Character Whether the patient had previous or recent lupus nephritis at the time of sampling Sm_status Character The sample's status of anti-Sm autoantibody at the time of sampling dsDNA_status Character The sample's status of anti-dsDNA autoantibody at the time of sampling La_status Character The sample's status of anti-La autoantibody at the time of sampling RNP_68_status Character The sample's status of anti-RNP-68 autoantibody at the time of sampling RNP_A_status Character The sample's status of anti-RNP-A autoantibody at the time of sampling Ro_52_status Character The sample's status of anti-Ro52 autoantibody at the time of sampling Ro_60_status Character The sample's status of anti-Ro60 autoantibody at the time of sampling Pred Character Patient's status of receiving Prednisolone at the time of sampling MMF Character Patient's status of receiving Mycophenolate mofetil at the time of sampling RTX Character Patient's status of receiving Rituximab at the time of sampling CYC Character Patient's status of receiving Cyclophosphamide at the time of sampling BEL Character Patient's status of receiving Belimumab at the time of sampling HCQ Character Patient's status of receiving Hydroxychloroquine at the time of sampling uPCR Numeric The patient's urine protein-creatinine ratio at the time of sampling Creatinine Numeric The patient's level of creatinine at the time of sampling Lymphocyte_count Numeric The patient's level of lymphocyte count at the time of sampling