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Tandem Diels−Alder/Fragmentation Approach to the Synthesis of Eleutherobin

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https://figshare.com/articles/dataset/Tandem_Diels_Alder_Fragmentation_Approach_to_the_Synthesis_of_Eleutherobin/3746805
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A synthesis of 28, the carbon framework of the eleutherobin aglycone, is reported in a 15-step sequence from readily available starting materials. The tandem Diels−Alder reaction of 6 and 7 to produce 18, in which three new rings and six new stereocenters are formed, is a key step in the reaction sequence.
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2016-08-20
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