Effect of volume overload on right ventricular remodeling in neonatal SD rats

We reported the RNAseq analyses of right ventricualr free wall myocardium in neonatal volume overload (VO) SD rat. VO was induced by the fistula between abdominal aorta and inferior vena cava (AVF) within 24 hours postnatally (P1). RNAseq analyses of RV free wall at P7 from VO and sham-operated rat revealed that there were 454 differentially expressed genes between VO and sham group at P7. GO analysis showed that in the VO and sham comparison, the upregulated genes mainly mediated immune system response and the downregulated genes mainly mediated apoptotic process at P7. VO has no effect to neonatal right ventricular cardiomyocyte proliferation.本数据集报告了新生期容量超负荷（volume overload, VO）SD大鼠右心室游离壁心肌组织的RNA测序（RNAseq）分析结果。研究于大鼠出生后24小时内（P1）通过构建腹主动脉与下腔静脉之间的动静脉瘘诱导容量超负荷模型。对P7时容量超负荷组与假手术组大鼠的右心室游离壁组织进行RNAseq分析，结果显示两组间共存在454个差异表达基因。基因本体（Gene Ontology, GO）分析表明，在P7时容量超负荷组与假手术组的比较中，上调基因主要介导免疫系统应答，而下调基因主要介导细胞凋亡过程。容量超负荷对新生大鼠右心室心肌细胞增殖无影响。