succinate + CoASH + GTP <=> succinylCoA + GDP + Pi

Mitochondrial succinyl-CoA synthetase catalyzes the reversible reaction of succinate, CoASH, and GTP to form succinylCoA, GDP, and orthophosphate. The enzyme is a heterodimer consisting of an alpha chain and a beta chain that determines whether the reaction involves adenine nucleotides or guanine nucleotides (as here). The biochemical properties of the chicken enzyme have been studied in detail (Hamilton and Ottaway 1981) but the genes encoding its component proteins have not been cloned. The molecular properties of these proteins are inferred from those of their pigeon homologues (Johnson et al. 1998).

线粒体琥珀酰辅酶A合酶催化琥珀酸、辅酶A（CoASH）和三磷酸鸟苷（GTP）的可逆反应，生成琥珀酰辅酶A、鸟苷二磷酸（GDP）和正磷酸。此酶由一个α链和一个β链组成的异源二聚体，该二聚体决定了反应中是否涉及腺嘌呤核苷酸或鸟嘌呤核苷酸（如本例所示）。关于鸡源酶的生化特性已有深入研究（Hamilton和Ottaway，1981年），但其组成蛋白编码基因尚未被克隆。这些蛋白的分子特性推断自其鸽源同源物的特性（Johnson等人，1998年）。