Matsuoka2003_VentricularCells_SinoatrialNodePacemaker

This a model from the article:
Role of individual ionic current systems in ventricular cells hypothesized by a
model study.

Matsuoka S, Sarai N, Kuratomi S, Ono K, Noma A. Jpn J Physiol
2003 Apr;53(2):105-23 12877767
,
Abstract:

Individual ion channels or exchangers are described with a common set of
equations for both the sinoatrial node pacemaker and ventricular cells. New
experimental data are included, such as the new kinetics of the inward rectifier
K+ channel, delayed rectifier K+ channel, and sustained inward current. The
gating model of Shirokov et al. (J Gen Physiol 102: 1005-1030, 1993) is used for
both the fast Na+ and L-type Ca2+ channels. When combined with a contraction
model (Negroni and Lascano: J Mol Cell Cardiol 28: 915-929, 1996), the
experimental staircase phenomenon of contraction is reconstructed. The
modulation of the action potential by varying the external Ca2+ and K+
concentrations is well simulated. The conductance of I(CaL) dominates membrane
conductance during the action potential so that an artificial increase of I(to),
I(Kr), I(Ks), or I(KATP) magnifies I(CaL) amplitude. Repolarizing current is
provided sequentially by I(Ks), I(Kr), and I(K1). Depression of ATP production
results in the shortening of action potential through the activation of I(KATP).
The ratio of Ca2+ released from SR over Ca2+ entering via I(CaL) (Ca2+ gain =
approximately 15) in excitation-contraction coupling well agrees with the
experimental data. The model serves as a predictive tool in generating testable
hypotheses.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Matsuoka S, Sarai N, Kuratomi S, Ono K, Noma A. (2003) - version=1.0

The original CellML model was created by:
Penny Noble

[e-mail]
The University of Oxford
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