Supplementary Material for: Campylobacter colitis as a trigger for atypical hemolytic uremic syndrome: about one case

Hemolytic uremic syndrome (HUS) belongs to the family of thrombotic microangiopathies (TMA). The diagnosis of HUS is suggested by the following triad: mechanical hemolytic anemia, thrombocytopenia and acute renal failure. In general, two types of HUS are distinguished: typical HUS, usually caused by Shiga toxin–producing Escherichia coli (STEC), and atypical HUS (aHUS) caused by deregulated complement activation. Here we present the case of a 17-year-old adolescent with factor H-associated aHUS, whose initial presentation was that of a typical diarrhea-associated HUS. The purpose of this article is to draw attention to this peculiar onset of an authentic aHUS and to stress the importance of analysing the alternate pathway of complement if the course of a supposedly typical HUS turns out to be unusual.