Proteomic analysis after interference with TERC in bladder cancer cell line

Muscle-invasive bladder cancer is closely associated with the susceptibility to metastasis and poor prognosis. In recent years, numerous studies have revealed that certain long non-coding RNAs (lncRNAs) may be involved in malignant progression of tumors. Here, we identified a lncRNA, telomerase RNA component (TERC), that is significantly upregulated in invasive bladder urothelial carcinoma tissues. We used in vitro and in vivo models to demonstrate its oncogenic effects. Mechanistically, we screened out the PPAR signaling pathway (RXRA, FABP3) regulated by TERC through proteomics and enrichment analysis.