Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map

Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... Authors: Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. Deposit date: 2023-05-15 Release date: 2023-10-11 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023基于复合图谱的双负载人源UBA7-UBE2L6-ISG15硫酯模拟复合物的冷冻电镜（Cryo-Electron Microscopy，Cryo-EM）结构 描述项：一磷酸腺苷（ADENOSINE MONOPHOSPHATE，AMP）、泛素样修饰物激活酶7（Ubiquitin-like modifier-activating enzyme 7，UBA7）、泛素样蛋白ISG15（Ubiquitin-like protein ISG15）…… 作者：Afsar M、Jia L、Ruben E.A、Olsen S.K. 提交日期：2023-05-15 发布日期：2023-10-11 最后更新日期：2025-05-28 实验方法：电子显微镜（分辨率3.38 Å） 引用文献：《UBA7的冷冻电镜结构揭示ISG15激活及E1-E2硫酯转移的分子基础》，《自然-通讯》（Nature Communications），2023年，第14卷