Gut microbiome of Type 2 diabetes mice

Type 2 diabetes, T2D, is a chronic metabolic disorder in which insulin resistance andimpaired insulin secretion result in altered metabolite balance, specifically elevated levels ofcirculating glucose and succinate, and increases the risk of many pathologies, includingperiodontitis. Succinate can be produced and metabolized by both host cells and host microbiota, where elevated levels serve as an inflammation and pathogen threat signal through activating the succinate G protein coupled receptor, SUCNR1. Modulating succinate-induced SUCNR1 signaling remains a promising therapeutic approach for pathologies resulting in elevated levels of succinate, such as T2D and periodontitis. Here, we performed16s rRNA gene sequencing on the fecal samples collected from the type 2 diabetes mice and WT healthy mice. Our data demonstrated that T2D mice harbored a significantly different gut microbiome, suggesting the altered metabolite profile of T2D causes shifts in host microbial community structure, with enrichment in succinate producers and consumers and mucin-degrading bacteria.