Dual-action strategy to reprogram chaperone activity for α-synuclein aggregate clearance in Parkinson's disease

This dataset contains raw research data obtained during the implementation of the project "Optymalizacja modelu in vitro komórek LUHMES opartego na patologii α-synukleiny do modelowania chorób neurodegeneracyjnych" (Optimization of the in vitro LUHMES cell model based on α-synuclein pathology for modeling neurodegenerative diseases). The shared data includes cellular biochemical profiles analyzed via FTIR spectroscopy, along with experimental results evaluating cell viability, metabolic activity, oxidative stress, aggresome formation, and molecular chaperone activation in human LUHMES cells. The study investigated the potential of a combined treatment using the natural compound resveratrol and lithium chloride against neurotoxicity induced by pre-formed α-synuclein fibrils (PFF) to model Parkinson's disease. The collected data serves as the empirical basis for both the original research paper and the patent application no. P. 448928. Funding acknowledgement: The research was supported by the National Science Centre (NCN), Poland, under the MINIATURA 7 grant, project No. 2023/07/X/NZ7/00153. Principal Investigator / Author: Oliwia Koszła本数据集包含于项目「Optymalizacja modelu in vitro komórek LUHMES opartego na patologii α-synukleiny do modelowania chorób neurodegeneracyjnych」（基于α-突触核蛋白（α-synuclein）病理的体外LUHMES细胞模型优化，用于神经退行性疾病建模）实施期间获取的原始研究数据。 本数据集所包含的共享数据涵盖通过傅里叶变换红外光谱（FTIR）分析得到的细胞生化特征谱，以及针对人LUHMES细胞的细胞活力、代谢活性、氧化应激、聚集体（aggresome）形成与分子伴侣激活情况进行评估的实验结果。本研究探究了天然化合物白藜芦醇（resveratrol）与氯化锂联合疗法对抗由预形成α-突触核蛋白纤丝（PFF）诱导的神经毒性的潜力，以此构建帕金森病模型。 本数据集收录的数据既是该原创研究论文的实证基础，同时也是专利申请号P. 448928的实验依据。 资助说明： 本研究得到波兰国家科学中心（National Science Centre, NCN）下属MINIATURA 7项目（项目编号：2023/07/X/NZ7/00153）的资助。 项目负责人/作者：奥利维娅·科什拉（Oliwia Koszła）