Risk prediction by continuous environmental risk score (ERS) using single-phenotype approacha (n = 3847).

aPollutants selected by single-phenotype regression (n = 13, 9, 5 and 27 for total cholesterol, HDL, LDL and triglyceride, respectively) to construct ERS which was computed in the validation data (n = 3847), with adjustment for base covariates and phenotype-specific micronutrients.bContinuous phenotypes dichotomized to be high vs. low by thresholds: 200 mg/dL for CHOL, 40 mg/dL (male) or 50 mg/dL (female) for HDL, 130 mg/dL for LDL and 150 mg/dL for TRIG.cadjusted for base covariates and phenotype-specific micronutrients.dModel 1 plus ERS constructed with coefficient estimates from single-pollutant models as weights.eModel 1 plus ERS constructed with coefficient estimates from multi-pollutant models as weights.fPredicted residual sums of squares.gArea under the receiver operating characteristic (ROC) curve and its 95% confidence interval computed with 2000 stratified bootstrap replicates.