Effects of SNPs on CSF t-tau and p-tau in Alzheimer’s disease.

Abbreviations: Chr, chromosome; SNP, single nucleotide polymorphism; n, number of cases; SD, standard deviation; t-tau, total tau; p-tau, phosphorylated tau; DM, dominant model; GWAS, genome-wide association studies.Risk allele according to AlzGene meta-analyses or study source in bold and underscored. Information on risk allele was not available for all studies. All CSF values are means (standard deviation). P-values based on mixed model analyses adjusted for age and gender; values in parenthesis () adjusted for age, gender and APOE-ε4 status. Analyses testing APOE adjusted for age and gender. Results for APOE are shown for comparative purposes.aNo cerebrospinal fluid measured because none of the participants carried the rs11754661 AA genotype.bNo longer significant after false discovery rate correction.