Table 2 in Spirornatas A-C from brown alga Turbinaria ornata: Anti-hypertensive spiroketals attenuate angiotensin-I converting enzyme

Table 2 Bioactivities of spirornatas A-C isolated from the organic extract of T. ornata and their molecular descriptors.
Bioactivities (IC 50)Spirornata ASpirornata BSpirornata CStandardsAnti-hypertensive activity aACE-I inhibition4.55 b ± 0.024.72 a ± 0.044.86 a ± 0.024.29 c ± 0.02 CP–Antioxidant activities bDPPH. scavenging1.14 c ± 0.051.25 b ± 0.021.42 a ± 0.021.46 a ± 0.04 P–ABTS +. scavenging1.28 c ± 0.011.34 b ± 0.021.71 a ± 0.041.69 a ± 0.05 P–Molecular descriptors cSpirornata ASpirornata BSpirornata Cα -tocopherolCaptoprilElectronicTPSA71.0688.1361.8329.4657.61PI (× 10 24 cm 3)41434553.5421.00StericMR (cm 3 /mol)105.84110.83119.80135.654.85MV (cm 3)348.9353.2357.7462.70170.7P (cm 3)882.4917.79521123.00463.4HydrophobicLog POW3.221.692.759.980.24
Different superscripts indicate the standards used for different activities; P-α- tocopherol; CP-captopril.
a Bioactivities were expressed as IC values (μM). Samples were analyzed in triplicate (n = 3) and expressed as mean ± standard deviation. Means followed by 50 different superscripts (a-c) within the same row indicated significant differences (P <0.05). The superscript "CP" designates the standard captopril.
b IC values (mM). The superscript "P" indicates the standard α -tocopherol. 50
c Structure-activity relationship analysis was carried out by using different molecular descriptors of the purified compounds as described in the text. tPSA, topological polar surface area; MV, molar volume; P, parachor; MR, molar refractivity; Log POW, logarithmic scale of the octanol-water partition coefficient; PI, polarizability.