Additional file 2 of The relationships between women’s reproductive factors: a Mendelian randomisation analysis

Additional file 2: Table S1 Relationships where bi-directional MR was performed due to unclear temporal ordering. Table S2 Relationships investigated. Table S3 Replication consortia and studies. Table S4 Genetic correlation results. Table S5 Primary analysis (IVW). Table S6 Negative control results. Table S7 Heterogeneity for primary analysis. Table S8 Additional MR methods in relation to primary analysis. Table S9 Egger intercept test for the primary analysis. Table S10 I-squared statistics. Table S11 MR PRESSO Global test for primary analysis. Table S12 MR PRESSO Outlier correction for primary analysis. Table S13 Steiger results for the primary analysis. Table S14 Steiger: SNPs found to be in the incorrect intended for the primary analysis direction. Table S15 Steiger filtered MR results for the primary analysis. Table S16 Split sample SNPs, R2, F stats and number of overlapping SNPs. Table S17 Split sample GWAS overlapping SNPs between samples. Table S18 IVW UKBB split sample results. Table S19 UKBB meta-analysed split sample results. Table S20 Replication SNPs, R2 and F stats. Table S21 IVW UKBB and replication results. Table S22 MRlap number of SNPs. Table S23 MRlap observed and corrected results. Table S24 MVMR findings adjusted for childhood body size (UK Biobank).

附加文件2：表S1展示了因时间顺序不明确而执行双向MR分析的关系。表S2列出了研究的关系。表S3详述了复制联盟及研究。表S4展示了遗传相关性结果。表S5展示了主要分析（IVW）的结果。表S6展示了阴性控制结果。表S7展示了主要分析中的异质性。表S8展示了与主要分析相关联的附加MR方法。表S9展示了主要分析的Egger截距检验结果。表S10展示了I-squared统计量。表S11展示了主要分析的MR PRESSO全局检验结果。表S12展示了主要分析的MR PRESSO异常值校正结果。表S13展示了Steiger分析的主要分析结果。表S14展示了Steiger分析中发现的定位错误SNPs。表S15展示了Steiger过滤后的主要分析MR结果。表S16展示了分样本SNPs、R2、F统计量和重叠SNPs的数量。表S17展示了样本间的GWAS重叠SNPs。表S18展示了IVW UKBB分样本结果。表S19展示了UKBB元分析的分样本结果。表S20展示了复制SNPs、R2和F统计量。表S21展示了IVW UKBB和复制结果。表S22展示了MRlap中SNPs的数量。表S23展示了MRlap观测值和校正后的结果。表S24展示了针对儿童体重的MVMR发现调整结果（UK Biobank）。